Let’s examine the guitar more closely. Imagine that the guitar’s low E string has a frequency of 1 Hz. (It’s really 82.4069 Hz; feel free to multiply everything in this next section by that number if you want actual frequencies.) You want your high E string to be tuned two octaves higher than the low one, at 4 Hz. Let’s see if you can get there by tuning the strings pairwise.
I also recommend looking for an amplifier with an open back if possible, since you’re going to need strength in the mid-range tones and not obfuscate the natural lows. Here are some of my favorite choices for the blues: